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M94A2656.TXT
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1994-10-25
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Document 2656
DOCN M94A2656
TI Tuberculosis in Brazilian HIV-infected children report 10 cases.
DT 9412
AU Hamamoto LA; Sato H; Sakane PT; Kamikawa J; Costa PS; Biondillo TA;
Marques HH; Dept. Pediatrics, Univ. Sao Paulo, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):254 (abstract no. PB0445). Unique
Identifier : AIDSLINE ICA10/94369919
AB Since 1985 our institution is attending HIV infected children (n = 145
cases, P2 or P1B) and because the high incidence of tuberculosis in our
State (50 cases/10(5) inhabitants) the authors have persistent suspicion
for tuberculosis when HIV children have respiratory symptons. METHODS:
The authors designed a protocol for evaluation of clinical, laboratorial
and epidemiologic features for children with pulmonary manifestations
and/or adenopathy associated with fever without response to conventional
antimicrobial therapy. Culture and acid-fast stain of gastric aspirates,
sputum, tracheal aspiration and/or bronchoalveolar lavage, skin testing
(PPD) and clinical response to antituberculous drugs were included.
RESULTS: Tuberculousis was diagnosed in ten HIV patients, despite five
of then were vaccinated perinatally. Seven of then had positive culture
for M. tuberculosis and the others had clinical and epidemiological
features and clinical response to antituberculous therapy. Side effects
were observed in only two children. Seven children had pulmonary
manifestation, four had adenopathy and one had disseminated
tuberculosis. Two children died and the other improved with therapy.
CONCLUSION: Tuberculosis is a highly significant coinfection in HIV
infected children, specially in developing countries.
DE Antitubercular Agents/ADVERSE EFFECTS/THERAPEUTIC USE AIDS-Related
Opportunistic Infections/*DIAGNOSIS/DRUG THERAPY Brazil Child
*Developing Countries Human HIV Infections/*DIAGNOSIS/DRUG THERAPY
Tuberculosis, Pulmonary/*DIAGNOSIS/DRUG THERAPY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).